LUKE: I was giving her directions for the quickest way back to Hartford. It was very romantic. I said you take a right at Deerfield, and you catch the I-5 and you take it south. Oh man, hot stuff.
LORELAI: That is so typical of you.
LORELAI: That is not the quickest way back to Hartford. Everybody knows that you take Main to Cherry to Lynwood and then grab the I-11. Everybody knows that Luke. Everybody, apparently, but you!
Neither of these directions are realistic. The I-5 is the main interstate highway on the west coast of the US, running along the Pacific coast between Mexico and Canada. Luke also says that you travel south to Hartford from Stars Hollow, even though everything in the show suggests that you would travel north-east to reach Hartford from the town. The I-11 is a highway in Nevada, running from the Arizona state line to the city of Henderson.
At least you learn a few street names in Stars Hollow. Main (presumably the main street of town they show all the time), Deerfield, Cherry, and Lynwood.