The title references two different works. One is William Shakespeare’s Romeo and Juliet, previously and frequently mentioned. In the play, Shakespeare refers to the main characters as “star cross’d lovers”, meaning that their relationship is destined to fail no matter how hard they try. The phrase comes from astrology, meaning that the stars are working against them (in the same sense that we say “don’t cross me”, to mean “don’t interferere with my plans”).
The other reference is to the 1970 comedy film Lovers and Other Strangers, directed by Cy Howard and based on the play of the same name by Renée Taylor and Joseph Bologna, who also co-wrote the screenplay for the film.
The movie revolves around the upcoming wedding of Mike (Michael Brandon) and Susan (Bonnie Bedelia), and the spotlight it shines upon the marriages of their family members. The film is notable for being the screen debut of actress Diane Keaton, who plays Mike’s sister-in-law. Lovers and Other Strangers was well-reviewed and successful at the box office; it won the Academy Award for Best Original Song (For All We Know).