LORELAI: I think I have gangrene.
RORY: You do not.

Gangrene is when the tissues of the body die due to lack of blood supply, most commonly on the feet and hands. The skin changes from red to black, accompanied by numbness, swelling, pain and skin breakdown. If caused by an infection, it may include fever or blood poisoning. Although there are numerous possible causes, diabetes and smoking are the most common culprits in “dry gangrene”. “Wet gangrene” is caused by bacteria, and the flesh rapidly becomes putrid and rotting. About 80% of people will die without treatment (20% with treatment), and amputation is usually necessary.

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