JAMIE: I flunked a pop quiz in poli-sci because I couldn’t stop thinking about you.
Poli-Sci, short for Political Science. A social science discipline dealing with governance and power, constitution and law, and the analysis of political thought, power, and behaviour.
It’s possible that Jamie is doing a Political Science major at Princeton, with plans to work in government and politics when he graduates.
The Annotated Gilmore Girls 