BABETTE: Hey Michel, I just hit F4 and the num lock key and the one with the little apple on it and it’s freaking out like it’s on acid or something.
MICHEL: Oy vey.
On acid, slang for taking the hallucinogenic drug LSD. (Babette seems to have hit the dashboard, the number lock, and the command key all at once, so the screen starts scrolling).
Oy vey, interjection used to express dismay, frustration, or grief. It is borrowed from Yiddish, loosely meaning “Oh woe is me”.
The Annotated Gilmore Girls 